Monday, November 5, 2012

Sperm DNA damage: Role of Antioxidants

It is now known that male fertility is compromised as a result of sperm DNA fragmentation. Many studies have suggested the implication of oxidative stress in the cause of Sperm DNA fragmentation.
Greco, et al. (2005) conducted a study to find out whether pathologically increased incidence of DNA fragmentation in ejaculated spermatozoa can be reduced by oral treatment with two antioxidants namely vitamins C and E.
The study followed sixty-four men with unexplained infertility having an elevated  percentage of DNA-fragmented spermatozoa (> or = 15%)  in the ejaculate. They were randomly separated into two groups. One group (antioxidant treatment group) received 1 g vitamin C and 1 g vitamin E daily for 2 months while the other (placebo group) received placebo.
Results revealed that the percentage of DNA-fragmented spermatozoa was markedly reduced in the antioxidant treatment group after the treatment as compared with the pretreatment values. However, no differences were found in the basic sperm parameters between the antioxidant treatment and the placebo group before or after treatment. Also, no difference in the incidence of sperm DNA fragmentation was observed in the placebo group pre and post-treatment.
These findings show that incidence of sperm DNA fragmentation can be efficiently treated by oral antioxidants in a relatively short period of about 2 month.


Reference:
Greco, E., Iacobelli, M., Rienzi, L., Ubaldi, F., Ferrero, S., Tesarik, J. 2005. Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment. J Androl; 26 (3):349-353.

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